A Novel Strategy For Treatment Of Rheumatoid Arthritis-INCIDENTS-XIYUANLU
A research paper published this week in the international open acce journal PLoS Medicine describes a po ible new experimental therapy for rheumatoid arthritis and other autoimmune inflammatory diseases. The researchers, led by Rikard Holmdahl from Lund University, exploits a new finding in a mouse model that lack of reactive oxygen ecies makes arthritis worse rather than, as had been expected, better in a mouse model with arthritis. Reactive oxygen ecies are thought to be important in defe e agai t pathoge . The researcher tested phytol, which increased oxidative burst in vivo, and found that it improved the arthritis in the mouse model with arthritis. In testing, also in mice, phytol showed comparative effectivene to standard therapies for arthritis such as anti-tumour necrosis factor-a and methotrexate. The authors conclude that these results "suggest a novel pathway of autoimmune inflammatory disease and po ibly a novel therapeutic strategy." A Per ective article by Andrew Cope, from Imperial College London, discu es the study's findings further.
Citation: Hultqvist M, Olof on P, Gelderman KA, Holmberg J, Holmdahl R (2006) A new arthritis therapy with oxidative burst inducers. PLoS Med 3(9): e348.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIO OF YOUR REPORT
CONTACT:
Rickard Holmdahl
Medical Inflammation Research
Experimental Medical Science
I11 BMC
Lund Universitet
Lund, 221 84 Sweden
###
About PLoS Medicine
PLoS Medicine is an open acce , freely available international medical journal. It publishes original research that enhances our understanding of human health and disease, together with commentary and analysis of important global health i ues. For more information, visit http://www.plosmedicine.org/
About the Public Library of Science
The Public Library of Science (PLoS) is a non-profit organization of scientists and physicia committed to making the world's scientific and medical literature a freely available public resource. For more information, visit http://www.plos.org/
All works published in PLoS Medicine are open acce . Everything is immediately available without cost to anyone, anywhere--to read, download, redistribute, include in databases, and otherwise use--subject only to the condition that the original authorship is properly attributed. Copyright is retained by the authors. The Public Library of Science uses the Creative Commo Attribution Lice e.
